The Fine Chemical Industry, 2000-2025

Mario Pagliaro lecturing at
            HOLOS PhD Winter School, Padua, 28-Jan-202628-Jan-2026 - "The Fine Chemical Industry, 2000-2025" was the topic of the invited lecture given today by Mario Pagliaro at PhD Winter School "Enabling Green and Sustainable Chemistry through a Holistic and Systems Thinking Approach".

Held at the University of Padua, Italy, from January 27 to 30, the School offered a broad and interdisciplinary approach to sustainable chemistry based on systems thinking combining technical insights with key topics such as life cycle analysis, circular design,  and the regulatory, social, and economic implications of chemical production.

Following the same approach, Dr Pagliaro presented in his lecture the technology, economic and policy drivers of change occurred in the fine chemical industry in the first quarter of the 21st century.

"It is no longer tenable" opened his lecture Dr Pagliaro "that PhD students in chemistry or in chemical engineering have a sophisticated knowledge of specialized domains of chemistry knowledge and they barely know the difference between fine and specialy chemicals, knowing at the same time very little about a huge and rapidly growing sector of the chemical industry such as fine chemicals".

Following a brief presentation of the industry's history and evolution, Italy's scholar went ahead presenting the organization, production infrastructure, and global distribution patterns of today's fine chemical industry.

He thus identified catalysis, continuous manufacturing, and digitalization as the technology drivers of change; and COVID-19, supply chain disruptions, and government responses as the policy factors driving substantial changes in the structure of the industry, including reshoring of fine chemical productions to Europe, Japan, and North America.

He then presented selected case studies from India, China, France and North America supporting his analysis.

Citing an editorial published in 1921 in Nature, a scientific journal published in Great Britain, for which "our future position depends upon our chemical ability, and hence upon the employment of skilled workers directed by trained chemists engaged in a successful organic chemical industry" the Italian chemist concluded that the events of 2020-2022 confirmed that a strong fine chemical industry is fundamental to national security and public health of all countries.

Hence, he concluded, education of undergrduate chemistry and chemical engineering students needs to be reshaped to include both practice-oriented training on the advanced chemical technologies enabling growth and change in the industry, and updated teaching of the very same economic, regulatory, and social implications of fine chemical productions preached by the organizers of the HOLOS School.

The HOLOS PhD Winter School

Organized by the University of Padua with support Italy's Chemical Society and chemical companies in collaboration with Monash University in Melbourne and the University of Bath (Great Britain), the School brought together in Padua, over four days, 76 participants and 28 international speakers.

Five case studies at HOLOS PhD
          Winter SchoolBesides PhD students from the organizing Universities, other doctoral candidates were from Germany, Great Britain, Slovenia, and Switzerland. Young researchers too attended the School, including Giovanna Li Petri and Giuseppe Angellotti from our Institute.

🇦🇺 19 participants from Monash University
🇮🇹 27 from the University of Padova
🇬🇧 2 from the University of Bath
🌐 19 additional PhD students from Italy, Europe, and beyond
🏭 7 participants from industry and research institutions

The School program combined lectures by leading experts with an industrial forum held on Friday, alongside hands-on workshops, where five student groups participants teamed up to explore real case studies and discuss challenges directly with specialists to eventually offer a presentation of the projects, which sparked numerous questions and comments:

 • Hands-on group work on 5 real-world case studies, guided by a systems-thinking methodology
 • Strong engagement from students and facilitators, culminating in high-level group presentations
 • Industrial Forum fostering dialogue between academia and industry
 • Contributions from 28 lecturers across Australia, UK, Italy, Germany, the Netherlands, and Switzerland

“Context matters as much as chemistry, so that we can avoid unintended consequences from widespread use of new chemistry technologies” said University of Bath Research Fellow Stephen Salve Doliente, giving a talk about why systems thinking is important in scaling up green chemistry technologies.

Five systems thinking/sustainable chemistry-oriented case studies - tyre microplastics, green ammonia, critical minerals, food biomass and pharma. Each group was facilitated by researchers from Monash Chemistry.

Professor Edward Buckingham nudged participant to use systems thinking to zoom in and out on the system to identify leverage points for meaningful action.

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